Endocrine Abstracts

Background: Generously supported by IPSEN)-->Hypopituitarism is considered to be a risk factor for cardiovascular disease and early death in humans. However, some studies showed that most patients with isolated GH deficiency or combined pituitary hormonal deficiency due to gene mutations (PROP 1, GH receptors gene, GH-1 gene) can survive to advanced age.Aim: To collect clinical data on patients with congenital ...

The rarest causes of primary aldosteronism are aldosterone producing carcinoma, ectopic aldosterone secretion and familial aldosteronism. There are also few cases reported of aldosterone and cortisol tumor cosecretion. We present a 38-year-old woman admitted to our hospital because of resistant hypertension, large adrenal tumor and hypokalemia. At age 32 hypertension was diagnosed, but routine laboratory and abdominal ultrasound examination were normal. Few months before admis...

Recent studies have reported that gangliosides, the sialic acid containing glycosphingolipids, are able to modulate many cellular functions. As reactive oxygen species (ROS) in human semen originate from both spermatozoa and infiltrating leukocytes, we aimed to investigate i) the ability of gangliosides to protect human spermatozoa from hydrogen peroxide (H2O2)-induced DNA and membrane damage and ii) the effect of gangliosides on the production of ROS by ...

IntroductionInfertility associated with hypergonadotropism is usually an unpromising condition related to acheiving fertilization. We describe the patient presented as oligoasthenoteratozoospermia (OAT syndrome), with laboratory primary hypergonadotropic hypogonadism but normal male fenotype, including typical male hair dustribution.Case descriptionmale, born 41 year ago, presented when he was 29 year old, as...

Arginine vasopressin deficiency (or central diabetes insipidus - CDI) is a rare disorder (1 in 25 000 individuals). It is characterised by decreased release of antidiuretic hormone (ADH) which results in polyuria and polydipsia. Majority of cases are acquired and caused by neurosurgery or head trauma, primary or secondary brain tumours, infiltrative diseases or autoimmune neurohypophysitis. Only about 5% of all reported cases are caused by genetic or congenital disorders. It h...

Aim of this study was to investigate head to head ACTH and cortisol responses to DDAVP and ghrelin in patients with CD. Study was approved by the local ethics committee and informed consent obtained. Nine patients with CD were submitted to ghrelin 1 μg/kg and DDAVP 10 μg bolus iv administration on two separate occasions. Blood was sampled at 0.15, 30, 45, 60, 90 min. for ACTH (ELISA) and cortisol (RIA, Cis, Bio International, France) measurements.<p class="abstex...

Background and aims: In many developing countries, diabetic foot is considered as a problem only when the patient develops a wound on the foot. Until that moment, the detection of changes in the neurovascular condition of the feet is rarely applied. The aim of this prospective, single centre study was to define factors associated with early cardiovascular mortality in diabetes.Materials and methods: 1345 patients under age 75 were included who were under...

Introduction: The standard management of Graves’ disease includes initial use of antithyroid drugs, while radioactive iodine ablation or thyroid surgery are later definitive treatment options. Management of thyrotoxicosis secondary to the use of amiodarone can be challenging as patients may not promptly respond to antithyroid or corticosteroid therapy, and thyrotoxicosis may be more harmful in those patients owing to the underlying cardiac disease. In rare thyrotoxicosis ...

Objectives: The Clinical Activity Score (CAS) is used to measure and classify Graves orbitopathy activity (GO). However, CAS is partly subjective, and the evaluation of its components is binary. As CAS is known to be correlated with TSH receptor antibodies (TRAb), we wanted to evaluate other immunological parameters in the peripheral blood as markers of GO activity.Methods: The study included 32 patients (19 females, 13 males). CAS was evaluated by a sin...

Introduction: Primary hyperparathyroidism (PHPT) is disorder of one or more parathyroid glands, characterized by inadequately increased PTH secretion, almost always followed by hypercalcemia. Calcitonin, secreted by parafollicular C-cells in thyroid gland, is hypocalcemic hormone which partly acts as physiological antagonist of PTH.Aim: To evaluate calcitonin response in calcium infusion test in patients with primary hyperparathyroidism.<p class="abs...